Tg(tetO-DRD2)2-5Kndl
Transgene Detail

Summary

• Symbol: Tg(tetO-DRD2)2-5Kndl
• Name: transgene insertion 2-5, Eric R Kandel
• MGI ID: MGI:5693386
• Transgene: Tg(tetO-DRD2)2-5Kndl Location: unknown
• Alliance: Tg(tetO-DRD2)2-5Kndl page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-DRD2)2-5Kndl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DRD2 (1813)

  Drd2	(MGI:94924)

• Mutation details: The tetO promoter, consisting of seven operator sequences of the E. coli Tn10 tetracycline resistance operon and a Cytomegalovirus (CMV) minimal promoter, drives expression on the human DRD2 (D2R) gene and hGHpA (2.1 kb of the human growth hormone gene harboring the hGH polyadenylation signal). (J:106982)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:106982 Kellendonk C, et al., Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning. Neuron. 2006 Feb 16;49(4):603-15
• All: 10 reference(s)