Adacm2^{MRL/MpJ-Fas-lpr/J}
QTL Variant Detail

Summary

• QTL variant: Adacm2^{MRL/MpJ-Fas-lpr/J}
• Name: autoimmune dacryoadenitis in MRL mice 2; MRL/MpJ-Fas^lpr/J
• MGI ID: MGI:5693410
• QTL: Adacm2 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: MRL/MpJ-Fas^lpr/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:153376

MRL/Mp-lpr/lpr mice spontaneously develop progressive dacryoadenitis and

Sialadenitis. A difference in severity of these diseases is evident when comparing MRL/Mp-lpr/lpr with C3H/lpr mice allowing for the mapping of these traits in a genome wide scan. From these strains, 527 (MRL/lpr _ C3H/lpr) F2 (MCF2) mice were employed for QTL linkage analysis. Phenotypic analysis for dacryoadenitis and sialadenitis indexed for lesions showed that MRL parents showed a much higher degree for lesions as did C3H parents. Further dacryoadenitis and sialadenitis are inherited as recessive in mice with a MRL background. The mapping was indicated in Table 1 of the reference. The following QTL were observed, in parenthesis is chr location, LOD score, nearest marker, and suggested cM location: Autoimmune dacryoadenitis in MRL mice; Adacm1 (Chr.1, LOD 4.0, D1Mit187, 64.1 cM), Adacm2 (Chr.2, LOD 3.7, D2Mit285, 88.4 cM), Adacm3 (Chr.5, LOD 3.1, D5Mit136, 63.9 cM), autoimmune sialadenitis in MRL mice, Asm3 (Chr.1, LOD16.8, D1Mit286, 16.8, 69 cM), Asm4 (Chr.2, LOD 5.6, D2Mit395, 65.3 cM), Asm5 (Chr.2, LOD 5.4,D2Mit22, 82.1 cM).

References

• Original: J:153376 Kamao T, et al., Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci. Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3257-65
• All: 1 reference(s)