Summary |
|
||||||||
Variant origin |
|
||||||||
Variant description |
|
||||||||
Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:153376MRL/Mp-lpr/lpr mice spontaneously develop progressive dacryoadenitis and Sialadenitis. A difference in severity of in these diseases is evident when comparing MRL/Mp-lpr/lpr with C3H/lpr mice allowing for the mapping of these traits in a genome wide scan. From these strains, 527 (MRL/lpr _ C3H/lpr) F2 (MCF2) mice were employed for QTL linkage analysis. Phenotypic analysis for dacryoadenitis and sialadenitis indexed for lesions showed that MRL parents showed a much higher degree for lesions as did C3H parents. Further dacryoadenitis and sialadenitis are inherited as recessive in mice with a MRL background. The mapping was indicated in Table 1 of the reference. The following QTL were observed, in parenthesis is chr location, LOD score, nearest marker and suggested cM location: Autoimmune dacryoadenitis in MRL mice ; Adacm1 (Chr.1, LOD 4.0, D1Mit187, 64.1 cM), Adacm2 (Chr.2, LOD 3.7, D2Mit285, 88.4 cM), Adacm3 (Chr.5, LOD 3.1, D5Mit136, 63.9 cM), autoimmune sialadenitis in MRL mice, Asm3 (Chr.1, LOD16.8, D1Mit286, 16.8, 69 cM), Asm4 (Chr.2, LOD 5.6, D2Mit395, 65.3 cM), Asm5 (Chr.2, LOD 5.4,D2Mit22, 82.1 cM). |
||||||||
References |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 10/29/2024 MGI 6.24 |
|
|