Tg(tetO-DRD3)3-10Kndl
Transgene Detail

Summary

• Symbol: Tg(tetO-DRD3)3-10Kndl
• Name: transgene insertion 3-10, Eric R Kandel
• MGI ID: MGI:5693547
• Synonyms: tetO-D3R
• Transgene: Tg(tetO-DRD3)3-10Kndl Location: unknown
• Alliance: Tg(tetO-DRD3)3-10Kndl page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-DRD3)3-10Kndl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DRD3 (1814)

  Drd3	(MGI:94925)

• Mutation details: The tetO promoter consisting of seven operator sequences of the E. coli Tn10 tetracycline resistance operon and a Cytomegalovirus (CMV) minimal promoter, drives expression of the human DRD3 (D3R) gene and hGHpA (2.1 kb of the human growth hormone gene harboring the hGH polyadenylation signal). (J:225565)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:225565 Simpson EH, et al., Selective overexpression of dopamine D3 receptors in the striatum disrupts motivation but not cognition. Biol Psychiatry. 2014 Nov 15;76(10):823-31
• All: 1 reference(s)