Desp4^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Desp4^C57BL/6J
• Name: despair 4; C57BL/6J
• MGI ID: MGI:5693608
• QTL: Desp4 Location: Chr6:37049830-37049830 bp Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:161399

The mobility variance exhibited via the Tail suspension Test (TST) was used to identified despair QTLs in mice. Low immobility strain RIIIS/J was mated to high immobility strains C57BL/6J and NZB/BlNJ to create 622 F2 offspring to map the difference in mobility. Significant QTLs were found in chromosomes 6 in the B6F2 cross, chromosome X in the NZBF2 cross and in chromosome X and 4 using mice from both crosses. The chromosome 6 QTL Desp4 mapped at position 37,022,895 bps with SNP rs3678202 ( LOD 4.001).Chromosome X (NZBF2) QTL Desp5 mapped at position 69,924,084 bps with SNPrs13483821 (LOD 5.795) . Chromosome 4 (combined cross) QTL Desp6 mapped at position 99,462,176 bps with rs13477868 (LOD 21.6) and again the combined cross showed Desp5 mapping inX at 61,160,361 bps with SNP rs13483784 (LOD 5.474). Authors indicate that chromosome X locus Gabra3 is a candidate for chromosome X QTL Desp5.

References

• Original: J:161399 Miller BH, et al., Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice. Mamm Genome. 2010 Jun;21(5-6):247-57
• All: 1 reference(s)