Tg(tetO-Comt)1Kndl
Transgene Detail

Summary

• Symbol: Tg(tetO-Comt)1Kndl
• Name: transgene insertion 1, Eric R Kandel
• MGI ID: MGI:5693612
• Synonyms: tet-O-Comt
• Transgene: Tg(tetO-Comt)1Kndl Location: unknown
• Alliance: Tg(tetO-Comt)1Kndl page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-Comt)1Kndl expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Comt (MGI:88470)

• Mutation details: The tetO promoter, consisting of seven operator sequences of the E. coli Tn10 tetracycline resistance operon and a Cytomegalovirus (CMV) minimal promoter, drives expression on the mouse Comt gene and hGHpA (2.1 kb of the human growth hormone gene harboring the hGH polyadenylation signal). (J:225566)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:225566 Simpson EH, et al., Genetic variation in COMT activity impacts learning and dopamine release capacity in the striatum. Learn Mem. 2014 Apr;21(4):205-14
• All: 1 reference(s)