Krcn2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Krcn2^C57BL/6J
• Name: keratoconus 2; C57BL/6J
• MGI ID: MGI:5693622
• QTL: Krcn2 Location: unknown Genetic Position: Chr13, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:81167

To map the QTL responsible for hereditary keratoconus a panel of backcross mice was generated by mating JKC (Japanese keratoconus) mice to BALB/cJ or C57BL/6J and backcrossing the F1s to JKC. The C57BL/6J backcross proved informative in that 41/331 mice exhibited a keratoconus-like phenotype. The 41 keratoconus positive mice coupled with 56 mice that did not exhibit the phenotype were utilized in mapping the phenotype to mouse Chromosome 13. The highest peak LOD score ( 5.13) was indicated in the region of D13Mit252 between cM 21.9 cM and 34 cM. Symbol Krcn2 represents this QTL region. Authors suggest Ctsj, Ctsr, Il9, Ctla2a, Eae13 and Lect2 as possible candidates for Krcn2.

References

• Original: J:81167 Tachibana M, et al., Hereditary keratoconus-like keratopathy in Japanese wild mice mapped to mouse Chromosome 13. Mamm Genome. 2002 Dec;13(12):692-5
• All: 1 reference(s)