Ednra^{tm7(Hand2)Hku}
Targeted Allele Detail

Summary

• Symbol: Ednra^{tm7(Hand2)Hku}
• Name: endothelin receptor type A; targeted mutation 7, Hiroki Kurihara
• MGI ID: MGI:5693853
• Synonyms: Ednra^Hand2
• Gene: Ednra Location: Chr8:78389658-78451081 bp, - strand Genetic Position: Chr8, 36.63 cM, cytoband C2
• Alliance: Ednra^{tm7(Hand2)Hku} page

Morphological transformation in Ednra^{tm7(Hand2)Hku}/Ednra⁺ ES cell-derived chimeric mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224515
• Parent Cell Line: ATOM1 (ES Cell)
• Strain of Origin: (C57BL/6 x 129)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Ednra^{tm7(Hand2)Hku} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hand2 (MGI:103580)

• Mutation details: The open reading frame of Hand2 followed by an FRT-flanked puromycin cassette was knocked into the neo cassette in exon 2 of Ednra^tm1Hku by RMCE. (J:224515)

Recombinase-mediated cassette exchange to generate the first-step targeted (Ednra^tm1Hku), lacZ-knocked-in (Ednra^tm2.1Hku), Edn1-knocked-in (Ednra^tm6(Edn1)Hku), and Hand2-knocked-in (Ednra^{tm7(Hand2)Hku}) alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ednra Mutation: 35 strains or lines available

References

• Original: J:224515 Sato T, et al., An endothelin-1 switch specifies maxillomandibular identity. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18806-11
• All: 1 reference(s)