Acad8^m1Ytc
Chemically induced Allele Detail

Summary

• Symbol: Acad8^m1Ytc
• Name: acyl-Coenzyme A dehydrogenase family, member 8; mutation 1, Yuan-Tsong Chen
• MGI ID: MGI:5693896
• Synonyms: Acad8^M
• Gene: Acad8 Location: Chr9:26885431-26910862 bp, - strand Genetic Position: Chr9, 12.0 cM
• Alliance: Acad8^m1Ytc page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C point mutation in exon 2 that results in a frame-shift mutation and premature stop codon that truncates te protein at lysine 50. Western blot analysis confirmed the absence of protein expression in the liver and kidney. (J:222356)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acad8 Mutation: 29 strains or lines available

References

• Original: J:222356 Sabbagha NG, et al., Alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice. Pediatr Res. 2011 Jul;70(1):31-6
• All: 1 reference(s)