Tg(NEFH-tTA)8Vle
Transgene Detail

Summary

• Symbol: Tg(NEFH-tTA)8Vle
• Name: transgene insertion 8, Virginia M-Y Lee
• MGI ID: MGI:5693898
• Synonyms: NEFH-tTA
• Transgene: Tg(NEFH-tTA)8Vle Location: unknown Genetic Position: Chr12, 1.0 cM
• Alliance: Tg(NEFH-tTA)8Vle page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H/HeJ)F1

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The construct consists of ~18 kbp of the human neurofilament heavy polypeptide promoter (NEFH; from BAC RP11-91J21) upstream of the tetracycline-regulated transactivator gene (tTA or "Tet-Off"), followed by a polyA signal. Founder line 8 has its highest tTA expression in developmental late stage of the cortex, cerebellum and hippocampus, with expression also observed in olfactory bulb and in the rest of the brain. (J:225639)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

References

• Original: J:225639 Walker AK, et al., Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43. Acta Neuropathol. 2015 Nov;130(5):643-60
• All: 15 reference(s)