Tbp^tm1.1Xjl
Targeted Allele Detail

Summary

• Symbol: Tbp^tm1.1Xjl
• Name: TATA box binding protein; targeted mutation 1.1, Xiao-Jiang Li
• MGI ID: MGI:5693900
• Synonyms: SCA17 KI
• Gene: Tbp Location: Chr17:15720150-15737689 bp, + strand Genetic Position: Chr17, 8.95 cM
• Alliance: Tbp^tm1.1Xjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213011
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Exon 2 was replaced with a floxed STOP, a neomycin resistance cassette and the corresponding human sequence for exon 2 with 105 CAG repeats. Cre-mediated recombination removed the floxed STOP, resulting in expression of the 105 CAG repeats. (J:213011)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbp Mutation: 10 strains or lines available

References

• Original: J:213011 Yang S, et al., Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice. Neuron. 2014 Jan 22;81(2):349-65
• All: 2 reference(s)