Ofcc1^tm1.2Tohn
Targeted Allele Detail

Summary

• Symbol: Ofcc1^tm1.2Tohn
• Name: orofacial cleft 1 candidate 1; targeted mutation 1.2, Tetsuo Ohnishi
• MGI ID: MGI:5693944
• Gene: Ofcc1 Location: Chr13:40155358-40514926 bp, - strand Genetic Position: Chr13, 19.45 cM
• Alliance: Ofcc1^tm1.2Tohn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223904
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 3 and 4. RT-PCR confirmed the absence of all three transcript variants in whole brain and trunk from E14.5 embryos. (J:223904)

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ofcc1 Mutation: 74 strains or lines available

References

• Original: J:223904 Ohnishi T, et al., Ablation of Mrds1/Ofcc1 induces hyper-gamma-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice. PLoS One. 2011;6(12):e29499
• All: 1 reference(s)