Il1r1^tm1.1Rbl
Targeted Allele Detail

Summary

• Symbol: Il1r1^tm1.1Rbl
• Name: interleukin 1 receptor, type I; targeted mutation 1.1, Randy D Blakely
• MGI ID: MGI:5694158
• Synonyms: IL1R^loxP
• Gene: Il1r1 Location: Chr1:40264240-40356417 bp, + strand Genetic Position: Chr1, 18.81 cM
• Alliance: Il1r1^tm1.1Rbl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241345
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector to insert a loxP site upstream of exon 3, containing the translation initiation sequence, and a second loxP site downstream of exon 4 of the interleukin 1 receptor, type I (Il1r1) gene. An FRT-flanked neomycin resistance (neo) cassette was placed downstream of the 3' loxP site. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:241345)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il1r1 Mutation: 39 strains or lines available

References

• Original: J:241345 Robson MJ, et al., Generation and Characterization of Mice Expressing a Conditional Allele of the Interleukin-1 Receptor Type 1. PLoS One. 2016;11(3):e0150068
• All: 24 reference(s)