Cimap2^Retro
Chemically induced Allele Detail

Summary

• Symbol: Cimap2^Retro
• Name: ciliary microtubule associated protein 2; Retro
• MGI ID: MGI:5694208
• Synonyms: Retro
• Gene: Cimap2 Location: Chr4:106448106-106474438 bp, - strand Genetic Position: Chr4, 49.67 cM
• Alliance: Cimap2^Retro page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Applicable)
• Mutation: Single point mutation
• Mutation details: This ENU-induced mutation was isolated in a screen for cytotoxic T lymphocyte response to LCMV C13 infection. Sequencing identified an A to G transition at nucleotide 1304 in exon 2. Western blot analysis reveals increased protein expression on total CD8+ T cells following LCMV infection. (J:223336)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cimap2 Mutation: 15 strains or lines available

References

• Original: J:223336 Okoye I, et al., T cell metabolism. The protein LEM promotes CD8(+) T cell immunity through effects on mitochondrial respiration. (Expression of Concern 350 (6267): 1482). Science. 2015 May 29;348(6238):995-1001
• All: 1 reference(s)