Podxl^tm2Kmn
Targeted Allele Detail

Summary

• Symbol: Podxl^tm2Kmn
• Name: podocalyxin-like; targeted mutation 2, Kelly M McNagny
• MGI ID: MGI:5694686
• Synonyms: Podxl^F, Podxl^flox
• Gene: Podxl Location: Chr6:31496428-31540872 bp, - strand Genetic Position: Chr6, 12.57 cM
• Alliance: Podxl^tm2Kmn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223453
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site followed by Frt-flanked neo cassette were inserted upstream of exon 3 and another loxP site in intron 7. Flp-mediated recombination removed neo cassette, leaving exons 3 through 7 floxed. (J:223453)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Podxl Mutation: 17 strains or lines available

References

• Original: J:223453 Debruin EJ, et al., Podocalyxin regulates murine lung vascular permeability by altering endothelial cell adhesion. PLoS One. 2014;9(10):e108881
• All: 4 reference(s)