Spns2^tm1Tni
Targeted Allele Detail

Summary

• Symbol: Spns2^tm1Tni
• Name: SPNS lysolipid transporter 2, sphingosine-1-phosphate; targeted mutation 1, Tsuyoshi Nishi
• MGI ID: MGI:5694845
• Gene: Spns2 Location: Chr11:72342464-72380730 bp, - strand Genetic Position: Chr11, 44.31 cM
• Alliance: Spns2^tm1Tni page

Spns2^tm1Tni/Spns2^tm1Tni mice show an eye-open at birth phenotype

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225108
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: A lacZ reporter gene and neomycin resistance cassette replaced part of exon 6 and exon 7, encoding the Arg200 that is essential for the S1P export activity. RT-PCR confirmed the absence of protein expression in the brain, liver, small intestine and stomach. (J:225108)

Generation of the Spns2^tm1Tni allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spns2 Mutation: 31 strains or lines available

References

• Original: J:225108 Hisano Y, et al., Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells. PLoS One. 2012;7(6):e38941
• All: 1 reference(s)