Ptprc^nim
Chemically induced Allele Detail

Summary

• Symbol: Ptprc^nim
• Name: protein tyrosine phosphatase receptor type C; nimbus
• MGI ID: MGI:5694925
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^nim page

Mutation origin

• Strain of Origin: C57BL/6JAnu
• Project Collection: APF ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a C to T point mutation upstream of exon 18 which introduces an introgenic 1 G nucleotide of the sonsensus splice acceptor sequence. The altered splice acceptor results in a frameshift and truncation at exon 18. Flow cytometry confirmed the absence of protein expression on the surface of B lymphocytes. (J:225105)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 189 strains or lines available

References

• Original: J:225105 Andrews TD, et al., Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models. Open Biol. 2012 May;2(5):120061
• All: 1 reference(s)