Socs2^tm1Vem
Targeted Allele Detail

Summary

• Symbol: Socs2^tm1Vem
• Name: suppressor of cytokine signaling 2; targeted mutation 1, Vicky E MacRae
• MGI ID: MGI:5695065
• Gene: Socs2 Location: Chr10:95221224-95253042 bp, - strand Genetic Position: Chr10, 49.35 cM
• Alliance: Socs2^tm1Vem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225936
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• An IRES beta-geo cassette was inserted into exon 2 downstream of the coding sequence. (J:225936)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Socs2 Mutation: 24 strains or lines available

References

• Original: J:225936 Macrae VE, et al., Increased bone mass, altered trabecular architecture and modified growth plate organization in the growing skeleton of SOCS2 deficient mice. J Cell Physiol. 2009 Feb;218(2):276-84
• All: 4 reference(s)