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Safb2tm1So
Targeted Allele Detail
Summary
Symbol: Safb2tm1So
Name: scaffold attachment factor B2; targeted mutation 1, Steffi Oesterreich
MGI ID: MGI:5695073
Gene: Safb2  Location: Chr17:56867965-56891585 bp, - strand  Genetic Position: Chr17, 29.39 cM
Alliance: Safb2tm1So page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:225512
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4-10 were replaced by an IRES-lacZ-SV40pA (beta-galactosidase) marker and a PGK-Neomycin-bGHpA selection cassette. Northern blot analysis indicated that no detectable transcript encoding the C-terminus is expressed from this allele. The N-terminus is expressed together with the introduced lacZ gene. LacZ is expressed in Sertoli cells. (J:225512)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Safb2 Mutation:  38 strains or lines available
References
Original:  J:225512 Jiang S, et al., Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1. Dis Model Mech. 2015 Sep 1;8(9):1121-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory