Upk3b^tm1.1Akis
Targeted Allele Detail

Summary

• Symbol: Upk3b^tm1.1Akis
• Name: uroplakin 3B; targeted mutation 1.1, Andreas Kispert
• MGI ID: MGI:5695209
• Synonyms: Upk3b^creERT2
• Gene: Upk3b Location: Chr5:136067350-136073847 bp, + strand Genetic Position: Chr5, 75.7 cM
• Alliance: Upk3b^tm1.1Akis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225159
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a tamoxifen-inducible cre recombinase gene (cre/ERT2) and floxed neomycin resistnace cassette. Cre-mediated recombination removed the selection cassette. In situ hybridization fails to detect cre expression. Semi-quantitative RT-PCR confirmed the absence of transcript expression in the heart at E12.5. (J:225159)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Upk3b^tm1.1Akis/Upk3b^tm1.1Akis	involves: 129P2/OlaHsd * NMRI

Phenotypes:

Affected Systems	hm1
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cardiovascular system	N
cardiovascular system phenotype	N
renal/urinary system	N
renal/urinary system phenotype	N

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

20 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Upk3b Mutation: 14 strains or lines available

References

• Original: J:225159 Rudat C, et al., Upk3b is dispensable for development and integrity of urothelium and mesothelium. PLoS One. 2014;9(11):e112112
• All: 1 reference(s)