Ank1^tm1Vso
Targeted Allele Detail

Summary

• Symbol: Ank1^tm1Vso
• Name: ankyrin 1, erythroid; targeted mutation 1, Vincenzo Sorrentino
• MGI ID: MGI:5695219
• Synonyms: sAnk1 KO
• Gene: Ank1 Location: Chr8:23464860-23640513 bp, + strand Genetic Position: Chr8, 11.42 cM
• Alliance: Ank1^tm1Vso page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223673
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: Exon 39a was replaced with neo cassette. Northern blot analysis confirmed the absence of transcript in hindlimb muscle. (J:223673)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ank1 Mutation: 106 strains or lines available

References

• Original: J:223673 Giacomello E, et al., Deletion of small ankyrin 1 (sAnk1) isoforms results in structural and functional alterations in aging skeletal muscle fibers. Am J Physiol Cell Physiol. 2015 Jan 15;308(2):C123-38
• All: 1 reference(s)