Lmna^tm1Rben
Targeted Allele Detail

Summary

• Symbol: Lmna^tm1Rben
• Name: lamin A; targeted mutation 1, Ricardo Benavente
• MGI ID: MGI:5695312
• Synonyms: Lamin C2^-
• Gene: Lmna Location: Chr3:88388455-88413842 bp, - strand Genetic Position: Chr3, 38.84 cM
• Alliance: Lmna^tm1Rben page

Small testes and absence of post-meiotic cells in the Lmna^tm1Rben/Lmna^tm1Rben testes

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223056
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Modified isoform(s)) Mutations: Insertion, Intragenic deletion Mutation details: A loxP-flanked neomycin resistance cassette replaced exon 1a. Western blot analysis confirmed the absence of isoform C2 protein expression in the testes without affected expression of isoform A/C in the testes and liver. (J:223056)

Generation of the Lmna^tm1Rben allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmna Mutation: 84 strains or lines available

References

• Original: J:223056 Link J, et al., The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouse. PLoS Genet. 2013;9(1):e1003261
• All: 2 reference(s)