Tysnd1^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Tysnd1^tm1.1Arte
• Name: trypsin domain containing 1; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5695314
• Gene: Tysnd1 Location: Chr10:61531293-61538552 bp, + strand Genetic Position: Chr10, 32.26 cM, cytoband B4
• Alliance: Tysnd1^tm1.1Arte page

Male Tysnd1^tm1.1Arte/Tysnd1^tm1.1Arte mice are infertile

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223054
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An addtional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette, exon 2 and exon 3. Western blot analysis confirmed the absence of protein expression in the liver. (J:223054)

Generation of the Tysnd1^tm1.1Arte allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tysnd1 Mutation: 14 strains or lines available

References

• Original: J:223054 Mizuno Y, et al., Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility. PLoS Genet. 2013;9(2):e1003286
• All: 1 reference(s)