Clcn7^tm5.1Tjj
Targeted Allele Detail

Summary

• Symbol: Clcn7^tm5.1Tjj
• Name: chloride channel, voltage-sensitive 7; targeted mutation 5.1, Thomas J Jentsch
• MGI ID: MGI:5695557
• Synonyms: Clcn7^E312A, Clcn7^td
• Gene: Clcn7 Location: Chr17:25352365-25381078 bp, + strand Genetic Position: Chr17, 12.53 cM, cytoband A3.3
• Alliance: Clcn7^tm5.1Tjj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217031
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: An E312A mutation was inserted in exon 11 and an FRT flanked neo cassette was inserted in intron 7 via homologous recombination. Flp mediated recombination removed the neo cassette. The mutant protein is ion-transport deficient but interaction competent. (J:217031)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clcn7 Mutation: 42 strains or lines available

References

• Original: J:217031 Weinert S, et al., Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions. EMBO Rep. 2014 Jul;15(7):784-91
• All: 1 reference(s)