Moe1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Moe1^C57BL/6J
• Name: modifier of epilepsy 1; C57BL/6J
• MGI ID: MGI:5696106
• QTL: Moe1 Location: Chr11:94770978-94771099 bp Genetic Position: Chr11, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:102036

The Authors carried out ten backcross generations in transferring the Scn2a^Q54 transgene onto the C57BL/6J background, thus creating congenic line C57BL/6J.Q54 (abbreviated B6.Q54).

Further the B6.Q54 congenic mice were crossed to strain SJL/J. Theresulting (SJL X B6)F1.Q54 offspring were abbreviated as F1.Q54. For mapping loci that modified epilepsy the F1.Q54 mice were backcrossed to C57BL/6J. Categorical trait interval mapping with a genome wide scan provided evidence for the existence of twomodifier loci one on mouse Chromosomes 11 and another on mouse 19. Moe1 mapped with Chromosome 11 and showed a peak at 54 cM (95 Mb) and is significantly associated with D11Mit289. The mouse Chromosome 19 locus Moe2 shows a peak at 24 cM (31.3 Mb) and has a significant association with D19Mit135

References

• Original: J:102036 Bergren SK, et al., Genetic modifiers affecting severity of epilepsy caused by mutation of sodium channel Scn 2 a. Mamm Genome. 2005 Sep;16(9):683-90
• All: 1 reference(s)