Tg(RP23-352G18)1Coppa
Transgene Detail

Summary

• Symbol: Tg(RP23-352G18)1Coppa
• Name: transgene insertion 1, Roberto Coppari
• MGI ID: MGI:5696226
• Synonyms: Sirt6BAC
• Transgene: Tg(RP23-352G18)1Coppa Location: unknown
• Alliance: Tg(RP23-352G18)1Coppa page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(RP23-352G18)1Coppa expresses 7 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ankrd24 (MGI:1890394)
  mouse	BC025920 (MGI:2670983)
  mouse	Gnl1 (MGI:95764)
  mouse	Sirt6 (MGI:1354161)
  mouse	Tle2 (MGI:104635)
  mouse	Tle5 (MGI:95806)
  mouse	Tle6 (MGI:2149593)

• Mutation details: The transgenic construct was made using C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-352G18 containing the entire sirtuin 6 locus (Sirt6) as well as 109 kbp of centromeric flanking sequences (including a portion of the Gna15 locus, several complete loci [Gna11, Aes, Tle2, Tle6, BC025920, Ankrd24] and predicted genes [Gm31878, Gm31936, Gm32024]) and 70 kbp of telomeric flanking sequences (including the predicted gene Gm10778). The RP23-352G18 BAC DNA was modified only by insertion of an ampicillin resistance cassette. Founder line 1 has a 2-4 fold greater expression of Sirt6 as compared to wild-type. (J:229077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:229077 Anderson JG, et al., Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6. Mol Metab. 2015 Nov;4(11):846-56
• All: 6 reference(s)