Nmt2^tm1.1Poru
Targeted Allele Detail

Summary

• Symbol: Nmt2^tm1.1Poru
• Name: N-myristoyltransferase 2; targeted mutation 1.1, Stefan Porubsky
• MGI ID: MGI:5696557
• Synonyms: Nmt2^f
• Gene: Nmt2 Location: Chr2:3285249-3329914 bp, + strand Genetic Position: Chr2, 1.84 cM
• Alliance: Nmt2^tm1.1Poru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226234
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 11. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream from exon 14. Flp-mediated recombination removed the selection cassette and left exons 11 through 14 floxed. (J:226234)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nmt2 Mutation: 30 strains or lines available

References

• Original: J:226234 Rampoldi F, et al., Immunosuppression and Aberrant T Cell Development in the Absence of N-Myristoylation. J Immunol. 2015 Nov 1;195(9):4228-43
• All: 2 reference(s)