Tg(Camk2a-SNCA*)2Mgsp
Transgene Detail

Summary

• Symbol: Tg(Camk2a-SNCA*)2Mgsp
• Name: transgene insertion 2, Maria Grazia Spillantini
• MGI ID: MGI:5696736
• Synonyms: CamS
• Transgene: Tg(Camk2a-SNCA*)2Mgsp Location: unknown
• Alliance: Tg(Camk2a-SNCA*)2Mgsp page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F1/J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-SNCA*)2Mgsp expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

  Transgene expresses a 120 amino acid truncated human gene.

• Mutation details: A human 120-amino acid truncated alpha-synuclein cDNA is under the control of the Camk2 1.3 alpha promoter. Three lines were generated (1, 2, and 3). These mice were crossed to C57BL/6JOlaHsd mice which lack alpha-synuclein as a result of a spontaneous deletion of the alpha-SNCA locus. (J:219640)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:219640 Hall K, et al., Behavioural deficits in transgenic mice expressing human truncated (1-120 amino acid) alpha-synuclein. Exp Neurol. 2015 Feb;264:8-13
• All: 1 reference(s)