Hmmr^tm1Plou
Targeted Allele Detail

Summary

• Symbol: Hmmr^tm1Plou
• Name: hyaluronan mediated motility receptor (RHAMM); targeted mutation 1, Aspasia Ploubidou
• MGI ID: MGI:5696779
• Synonyms: hmmr^m
• Gene: Hmmr Location: Chr11:40592222-40624249 bp, - strand Genetic Position: Chr11, 24.4 cM
• Alliance: Hmmr^tm1Plou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221355
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette with in-frame stop codons replaced intron 10. This premature truncation abolishes the centrosome targeting domain containing the hyaluronic acid (HA) binding site. Western blot analysis confirmed the production of a smaller than normal protein. (J:221355)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmmr Mutation: 47 strains or lines available

References

• Original: J:221355 Li H, et al., RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility. Biol Open. 2015;4(4):562-71
• All: 2 reference(s)