Adamtsl2^{tm1b(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Adamtsl2^{tm1b(KOMP)Wtsi}
• Name: ADAMTS-like 2; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:5696789
• Gene: Adamtsl2 Location: Chr2:26969391-26998993 bp, + strand Genetic Position: Chr2, Syntenic
• Alliance: Adamtsl2^{tm1b(KOMP)Wtsi} page
• IMPC: Adamtsl2 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221347
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The loxP-flanked neomycin selection cassette and exon 5 of Adamtsl2^{tm1a(KOMP)Wtsi} were deleted via cre-mediated recombination. This allele expresses the lacZ gene under the control of the endogenous gene promoter. (J:221347)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamtsl2 Mutation: 33 strains or lines available

References

• Original: J:221347 Hubmacher D, et al., Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia - a novel mouse model providing insights into geleophysic dysplasia. Dis Model Mech. 2015 May 1;8(5):487-99
• All: 3 reference(s)