Pkd1^tm2Pcha
Targeted Allele Detail

Summary

• Symbol: Pkd1^tm2Pcha
• Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 2, Peter C Harris
• MGI ID: MGI:5697038
• Synonyms: Pkd1^del31
• Gene: Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
• Alliance: Pkd1^tm2Pcha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220561
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 31-34 were replaced with a selection cassette, resulting in a frameshift at exon 31 and truncating polycystin-1 in the second cytoplasmic loop. (J:220561)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd1 Mutation: 154 strains or lines available

References

• Original: J:220561 Gainullin VG, et al., Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner. J Clin Invest. 2015 Feb;125(2):607-20
• All: 1 reference(s)