Setx^tm1.1Mfl
Targeted Allele Detail

Summary

• Symbol: Setx^tm1.1Mfl
• Name: senataxin; targeted mutation 1.1, Martin F Lavin
• MGI ID: MGI:5697060
• Gene: Setx Location: Chr2:29014193-29072483 bp, + strand Genetic Position: Chr2, 19.45 cM
• Alliance: Setx^tm1.1Mfl page

Small testis size and disrupted spermatogenesis in Setx^tm1.1Mfl/Setx^tm1.1Mfl mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223053
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed neomycin resistance cassette replaced exon 4. Cre-mediated recombination removed the selection cassette. Western blot analysis confirmed the absence of protein expression in testes. (J:223053)

Generation of the Setx^tm1.1Mfl allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setx Mutation: 141 strains or lines available

References

• Original: J:223053 Becherel OJ, et al., Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing. PLoS Genet. 2013 Apr;9(4):e1003435
• All: 6 reference(s)