Pde9a^tm1Pfi
Targeted Allele Detail

Summary

• Symbol: Pde9a^tm1Pfi
• Name: phosphodiesterase 9A; targeted mutation 1, Pfizer, Ltd
• MGI ID: MGI:5697082
• Gene: Pde9a Location: Chr17:31605184-31695284 bp, + strand Genetic Position: Chr17, 16.23 cM
• Alliance: Pde9a^tm1Pfi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220465
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 12 was replaced with a lacZ-neomycin cassette in the catalytic domain of the carboxy terminal of the gene via homologous recombination. (J:220465)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde9a Mutation: 45 strains or lines available

References

• Original: J:220465 Lee DI, et al., Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease. Nature. 2015 Mar 26;519(7544):472-6
• All: 4 reference(s)