Slc39a3^tm1.1Gka
Targeted Allele Detail

Summary

• Symbol: Slc39a3^tm1.1Gka
• Name: solute carrier family 39 (zinc transporter), member 3; targeted mutation 1.1, Glen K Andrews
• MGI ID: MGI:5697153
• Synonyms: neo-negative ZIP3^-, ZIP3^-
• Gene: Slc39a3 Location: Chr10:80864374-80873169 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Slc39a3^tm1.1Gka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108627
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the gene following the translation initiating ATG was deleted and replaced by an EGFP open reading frame followed by a loxP-flanked neomycin selection cassette, which subsequently was excised in the germline by cre recombinase. Expression of EGFP is driven by the endogenous promoter. (J:99161, J:108627)

Expression

In Mice Carrying this Mutation:

11 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc39a3 Mutation: 12 strains or lines available

References

• Original: J:108627 Dufner-Beattie J, et al., Mouse ZIP1 and ZIP3 genes together are essential for adaptation to dietary zinc deficiency during pregnancy. Genesis. 2006 May;44(5):239-51
• All: 5 reference(s)