Elfn1^tm1.1Jaru
Targeted Allele Detail

Summary

• Symbol: Elfn1^tm1.1Jaru
• Name: leucine rich repeat and fibronectin type III, extracellular 1; targeted mutation 1.1, Jun Aruga
• MGI ID: MGI:5697443
• Gene: Elfn1 Location: Chr5:139893698-139960477 bp, + strand Genetic Position: Chr5, 78.81 cM
• Alliance: Elfn1^tm1.1Jaru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226212
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire 3.5 kb open-reading frame was replaced with a floxed phosphoglycerol kinase (PGK)-neo expression cassette. The neo cassette was subsequently excised by cre mediated recombination. Western blot analysis confirmed absence of protein. (J:226212)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Elfn1 Mutation: 32 strains or lines available

References

• Original: J:226212 Tomioka NH, et al., Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures. Nat Commun. 2014;5:4501
• All: 1 reference(s)