Aasm1^{B6.129P2-Apoe-tm1Unc/J}
QTL Variant Detail

Summary

• QTL variant: Aasm1^{B6.129P2-Apoe-tm1Unc/J}
• Name: aortic aneurysm 1; B6.129P2-Apoe^tm1Unc/J
• MGI ID: MGI:5697463
• QTL: Aasm1 Location: unknown Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: B6.129P2-Apoe^tm1Unc/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:182797

Linkage analysis was performed on 332 (B6.129P2-Apoe-tm1Unc/J x C3.129P2(B6)-Apoe-tm1Unc)F2 intercross mice using 1347 markers to identify QTL associated with aortic medial disruption. Parental strain C3H/HeJ displays higher susceptibility to aortic medial disruption than C57BL/6J.

QTL Aasm1 maps to 43.7 - 127.5 Mb on Chromosome 6 with a peak LOD score of 6.81 (sex-covariate) or 5.93 (sex-interaction) at 74 cM in linkage with aortic medial disruption. Because of an inversion in the C3H/HeJ strain on chromosome 6, 74 cM may not accurately reflect the actual peak location of the Aasm1 QTL. C57BL/6J alleles confer decreased susceptibility to aortic medial disruption at the Aasm1 locus.

References

• Original: J:182797 Wang SS, et al., Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice. Circ Cardiovasc Genet. 2009 Dec;2(6):573-82
• All: 1 reference(s)