Ccnc^tm1.1Pisc
Targeted Allele Detail

Summary

• Symbol: Ccnc^tm1.1Pisc
• Name: cyclin C; targeted mutation 1.1, Piotr Sicinski
• MGI ID: MGI:5697676
• Synonyms: Ccnc^F, Cyclin C^F
• Gene: Ccnc Location: Chr4:21727705-21759917 bp, + strand Genetic Position: Chr4, 8.86 cM
• Alliance: Ccnc^tm1.1Pisc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217695
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into the PvuII site in intron 1 and into the KpnI site in intron 7. In addition, a neomycin resistance (Neo) cassette, flanked by two FRT sites, was inserted into the PvuII site in intron 1. Resulting animals were then bred with FLPe-expressing mice resulting in the deletion of the Neo cassette. (J:217695)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccnc Mutation: 27 strains or lines available

References

• Original: J:217695 Li N, et al., Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol. 2014 Nov;16(11):1080-91
• All: 3 reference(s)