Cdk3^rs27030777-A
Spontaneous Allele Detail

Summary

• Symbol: Cdk3^rs27030777-A
• Name: cyclin dependent kinase 3; rs27030777 SNP allele with the A variant
• MGI ID: MGI:5697686
• Synonyms: Cdk3^m1
• Gene: Cdk3 Location: Chr11:116106829-116111113 bp, + strand Genetic Position: Chr11, 81.02 cM, cytoband E2
• Alliance: Cdk3^rs27030777-A page

Mutation origin

• Strain of Origin: various

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Single point mutation
• Mutation details: The mutation is a G-to-A point mutation in the third position of codon 187 that converts the TGG codon for a highly conserved tyrptophan within kinase consensus domain IX to a premature TGA termination codon (p.Trp187*). This A variant is the major variant found in the reference C57BL/6 and most other strains. The G variant is found in the AKR/J, CAST/EiJ, LG/J, MOLF/EiJ, PWD/PhJ, PWK/PhJ, and SPRET/EiJ strains. (J:67545)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk3 Mutation: 4 strains or lines available

Notes

This mutation is found in several M. musculus strains: C57BL/6J, BALB/c, 129/Sv (substrain not specified), B6D2F1 and FVB/NJ. CAST/Ei and CASA/Rk do not carry this mutation (J:67545).

References

• Original: J:67545 Ye X, et al., A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1682-6
• All: 2 reference(s)