Summary |
|
||||||||||
Variant origin |
|
||||||||||
Variant description |
|
||||||||||
Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:23719NZB and NZW mice spontaneously develop an autoimmune process remarkably simiar to human systemic lupus erythematosus. To identify additional NZB contributors to lupus like disease 90 female (NZB x SM/J)F1 x NZW backcross mice were followed for the development of sever renal disease and were comprehensively phenotyped. To identify disease associated loci the same mice were genotyped using PCR. A statistically significant association with disease was noted at 6 separate locations on Chrs 1, 4, 7, 10, 13 and 19. p<0.05 was the cutoff to define statistical significance. Mice carrying the NZB allele at five of these 6 positions died from severe renal disease.Of the six significant loci evident in the backcross, the level of association with disease at the Chromosome 1 locus was particularly strong, p<0.02, peaking with marker D1Mit111 at 61cM. This QTL has been named Nba2.The Chromosome 7 locus has been labeled Nba3, peaking with marker D7Mit17, p<0.008 at 45.0cM |
||||||||||
References |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/02/2024 MGI 6.24 |
![]() |
|