Nba3^NZB
QTL Variant Detail

Summary

• QTL variant: Nba3^NZB
• Name: New Zealand Black autoimmunity 3; NZB
• MGI ID: MGI:5697802
• QTL: Nba3 Location: Chr7:108482996-108483156 bp Genetic Position: Chr7, cM position of peak correlated region/allele: 48.36 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZB

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:23719

NZB and NZW mice spontaneously develop an autoimmune process remarkably simiar to human systemic lupus erythematosus. To identify additional NZB contributors to lupus like disease 90 female (NZB x SM/J)F1 x NZW backcross mice were followed for the development of sever renal disease and were comprehensively phenotyped. To identify disease associated loci the same mice were genotyped using PCR.

A statistically significant association with disease was noted at 6 separate locations on Chrs 1, 4, 7, 10, 13 and 19. p<0.05 was the cutoff to define statistical significance. Mice carrying the NZB allele at five of these 6 positions died from severe renal disease.

Of the six significant loci evident in the backcross, the level of association with disease at the Chromosome 1 locus was particularly strong, p<0.02, peaking with marker D1Mit111 at 61cM. This QTL has been named Nba2.

The Chromosome 7 locus has been labeled Nba3, peaking with marker D7Mit17, p<0.008 at 45.0cM

References

• Original: J:23719 Drake CG, et al., Analysis of the New Zealand Black contribution to lupus-like renal disease. Multiple genes that operate in a threshold manner. J Immunol. 1995 Mar 1;154(5):2441-7
• All: 1 reference(s)