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Pcdh15tm2.1Mll
Targeted Allele Detail
Summary
Symbol: Pcdh15tm2.1Mll
Name: protocadherin 15; targeted mutation 2.1 Ulrich Muller
MGI ID: MGI:5697806
Synonyms: deltaCD2, exon38KO, PCDH15-deltaCD2
Gene: Pcdh15  Location: Chr10:72935174-74485569 bp, + strand  Genetic Position: Chr10, 37.43 cM
Alliance: Pcdh15tm2.1Mll page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171627
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutation:    Intragenic deletion
 
Mutation detailsAn FRT-flanked neomycin selection cassette replaced exon 38. The neo cassette was subsequently removed by crossing the mice carrying the targeted allele to Flp-deleter mice. qPCR and in situ hybridization analyses of P1 homozygous mutant mice confirmed that expression of the CD2 isoform is abolished while expression of isoforms CD1 and CD3 is maintained. (J:171627)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pcdh15 Mutation:  135 strains or lines available
References
Original:  J:171627 Webb SW, et al., Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain. Development. 2011 Apr;138(8):1607-17
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory