Tg(Plp1-LMNB1)1108Qsp
Transgene Detail

Summary

• Symbol: Tg(Plp1-LMNB1)1108Qsp
• Name: transgene insertion 1108, Quasar S Padiath
• MGI ID: MGI:5697874
• Synonyms: Plp-FLAG-LMNB1
• Transgene: Tg(Plp1-LMNB1)1108Qsp Location: unknown
• Alliance: Tg(Plp1-LMNB1)1108Qsp page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Plp1-LMNB1)1108Qsp expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LMNB1 (4001)

  Lmnb1

  (MGI:96795)

• Mutation details: The murine proteolipid protein 1 promoter drives oligodendrocyte-specific expression of a full-length human lamin B1 cDNA with a FLAG tag at the 5' end. Two lines were established: 1108 and 1081. Line 1108 is entered as a representative line. (J:226169)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:226169 Rolyan H, et al., Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression. J Neurosci. 2015 Aug 26;35(34):12002-17
• All: 2 reference(s)