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Tsc22d3tm1.2Hum
Targeted Allele Detail
Summary
Symbol: Tsc22d3tm1.2Hum
Name: TSC22 domain family, member 3; targeted mutation 1.2, Edith Hummler
MGI ID: MGI:5698178
Synonyms: Tsc22d3-2delta
Gene: Tsc22d3  Location: ChrX:139440277-139501257 bp, - strand  Genetic Position: ChrX, 61.35 cM, cytoband F1
Alliance: Tsc22d3tm1.2Hum page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:223992
Parent Cell Line:  2A (ES Cell)
Strain of Origin:  129S1/SvImJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn Frt-flanked neomycin selection cassette followed by one loxP site was inserted 3' to the polyadenylation sites of the gene. A second loxP site was inserted 5' to exon 3. Exons 5 and 6 are common exons present in all three isoforms and are reffered as exon 3-4 in J:273574 for similar construct used to create an allele Tsc22d3. The loxP flanked sequences, including exons 3-6 and the Frt-flanked neomycin selection cassette, were removed via Cre-mediated recombination. (J:223992)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tsc22d3 Mutation:  5 strains or lines available
References
Original:  J:223992 Suarez PE, et al., The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility. Mol Endocrinol. 2012 Jun;26(6):1000-13
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory