Socs1^tm1.1Ayr
Targeted Allele Detail

Summary

• Symbol: Socs1^tm1.1Ayr
• Name: suppressor of cytokine signaling 1; targeted mutation 1.1, Alexander Y Rudensky
• MGI ID: MGI:5698257
• Synonyms: SOCS1^KI
• Gene: Socs1 Location: Chr16:10601672-10603400 bp, - strand Genetic Position: Chr16, 5.81 cM
• Alliance: Socs1^tm1.1Ayr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226678
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting construct is designed to insert a loxP-flanked neomycin resistance cassette downstream of exon 1 of the gene. Mutations (AGCTTAA to AGCAAATT) were introduced in the 3' UTR, corresponding to the putative miR-155 (microRNA 155) target site, resulting in a non-sense mutation. Cre-mediated recombination removed the floxed neo cassette. (J:226678)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Socs1^tm1.1Ayr/Socs1^tm1.1Ayr	involves: C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
hematopoietic system	√
decreased effector memory T-helper cell number	√
abnormal T cell physiology	√
immune system	√
decreased effector memory T-helper cell number	√
abnormal T cell physiology	√
decreased susceptibility to experimental autoimmune encephalomyelitis	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Socs1 Mutation: 30 strains or lines available

References

• Original: J:226678 Lu LF, et al., A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner. Immunity. 2015 Jul 21;43(1):52-64
• All: 1 reference(s)