Cd160^tm1Yxf
Targeted Allele Detail

Summary

• Symbol: Cd160^tm1Yxf
• Name: CD160 antigen; targeted mutation 1, Yang-Xin Fu
• MGI ID: MGI:5698520
• Gene: Cd160 Location: Chr3:96706079-96736667 bp, - strand Genetic Position: Chr3, 41.99 cM
• Alliance: Cd160^tm1Yxf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222131
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector was designed to replace exon 2 with a PGK-neo cassette. Exon 2 contains the initiation codon and is required for all splice variants. Removal of exon 2 forces downstream exons out of frame. Testing by immunohistochemistry confirms the absence of protein. (J:222131)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd160 Mutation: 17 strains or lines available

References

• Original: J:222131 Tu TC, et al., CD160 is essential for NK-mediated IFN-gamma production. J Exp Med. 2015 Mar 9;212(3):415-29
• All: 6 reference(s)