Lhx1^{tm1.1(icre)Rob}
Targeted Allele Detail

Summary

• Symbol: Lhx1^{tm1.1(icre)Rob}
• Name: LIM homeobox protein 1; targeted mutation 1.1, Elizabeth J Robertson
• MGI ID: MGI:5698524
• Synonyms: Lhx1^iCreIRESLacZ, Lhx1^iCre-LacZ, Lhx1^iCre-nLacZ, Lhx1^iCrenLacZ
• Gene: Lhx1 Location: Chr11:84409110-84416361 bp, - strand Genetic Position: Chr11, 51.31 cM
• Alliance: Lhx1^{tm1.1(icre)Rob} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226614
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase, Reporter)
• Mutation: Insertion
• Lhx1^{tm1.1(icre)Rob} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lhx1 (MGI:99783)

• Mutation details: The targeting construct inserted in frame with exon 1 an improved cre recombinase gene (icre), IRES, nuclear lacz reporter gene and FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the recombinase gene. (J:226614)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lhx1 (mouse) Summary of all recombinase alleles driven by Lhx1. Comparative matrix view of recombinase activities Alliance mouse Lhx1 gene page

Expression

In Mice Carrying this Mutation:

36 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhx1 Mutation: 22 strains or lines available

References

• Original: J:226614 Costello I, et al., Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 2015 Oct 15;29(20):2108-22
• All: 1 reference(s)