Ret^tm1.2Ddg
Targeted Allele Detail

Summary

• Symbol: Ret^tm1.2Ddg
• Name: ret proto-oncogene; targeted mutation 1.2, David D Ginty
• MGI ID: MGI:5698695
• Gene: Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
• Alliance: Ret^tm1.2Ddg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126484
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exons 14 and 15 and an FRT-flanked neo cassette are flanked by loxP sites. A missense mutation in exon 15 changes valine 805 to alanine. This mutation is silent but sensitizes the protein to chemical inhibition of its kinase activity. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 14 and 15 floxed. (J:126484)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ret Mutation: 54 strains or lines available

References

• Original: J:126484 Luo W, et al., A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007 Jun 7;54(5):739-54
• All: 9 reference(s)