Cbfb^tm2.1Ddg
Targeted Allele Detail

Summary

• Symbol: Cbfb^tm2.1Ddg
• Name: core binding factor beta; targeted mutation 2.1, David D Ginty
• MGI ID: MGI:5698728
• Synonyms: Cbfb^f
• Gene: Cbfb Location: Chr8:105897306-105944621 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Cbfb^tm2.1Ddg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226826
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin cassette and loxP site were introduced 1 kb upstream of the transcription start site, and a second loxP site was place in intron 2. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:226826)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cbfb Mutation: 36 strains or lines available

References

• Original: J:226826 Huang S, et al., Extrinsic and intrinsic signals converge on the Runx1/CBFbeta transcription factor for nonpeptidergic nociceptor maturation. Elife. 2015;4:e10874
• All: 5 reference(s)