Brinp1^tm1Imts
Targeted Allele Detail

Summary

• Symbol: Brinp1^tm1Imts
• Name: bone morphogenic protein/retinoic acid inducible neural specific 1; targeted mutation 1, Ichiro Matsuoka
• MGI ID: MGI:5698819
• Synonyms: BRINP1-KO
• Gene: Brinp1 Location: Chr4:68679751-68872634 bp, - strand Genetic Position: Chr4, 35.03 cM, cytoband C2
• Alliance: Brinp1^tm1Imts page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221295
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of Brinp1 exon8 was replaced by a PGK-neomycin resistance cassette. Northern blot analysis confirmed absence of mRNA transcript in the brain of adult homozygous mutant mice. (J:221295)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brinp1 Mutation: 30 strains or lines available

References

• Original: J:221295 Kobayashi M, et al., Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders. Mol Brain. 2014;7:12
• All: 2 reference(s)