Clcn3^tm1.1Jrhm
Targeted Allele Detail

Summary

• Symbol: Clcn3^tm1.1Jrhm
• Name: chloride channel, voltage-sensitive 3; targeted mutation 1.1, Joseph R Hume
• MGI ID: MGI:5699055
• Synonyms: Clcn3^c
• Gene: Clcn3 Location: Chr8:61363423-61436334 bp, - strand Genetic Position: Chr8, 30.9 cM
• Alliance: Clcn3^tm1.1Jrhm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222375
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 5' to exon 3 and a loxP site and an frt-flanked neomycin selection cassette was inserted 3' to exon 3. The neomcyin selection cassette was removed by Flp-mediated recombination. (J:222375)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clcn3 Mutation: 120 strains or lines available

References

• Original: J:222375 Xiong D, et al., Cardiac-specific, inducible ClC-3 gene deletion eliminates native volume-sensitive chloride channels and produces myocardial hypertrophy in adult mice. J Mol Cell Cardiol. 2010 Jan;48(1):211-9
• All: 1 reference(s)