Pas16^A/J
QTL Variant Detail

Summary

• QTL variant: Pas16^A/J
• Name: pulmonary adenoma susceptibility 16; ^A/J
• MGI ID: MGI:5699083
• QTL: Pas16 Location: unknown Genetic Position: Chr19, Syntenic

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers susceptibility to lung tumorigenesis compared to C57BL/6J.

  Pas15 and Pas16 appear to interact. Heterozygosity at both Pas15 and Pas16 confers increased tumor count compared to the other genotypes.

  (J:22173)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:22173

Linkage analysis using 77 polymorphic markers was performed on a population of (A/J x C57BL/6J)F1 x C57BL/6J backcross animals to identify QTLs associated with pulmonary adenoma susceptibility. Parental strain A/J is susceptible to ENU-induced pulmonary adenomas whereas parental strain C57BL/6J is resistant.

A QTL, peak LOD=4.78 was localized to a region of Chromosome 6 flanked by Kras and closely linked distal markers linked with D6Int1.

12.14.2015. Curator Note: Authors have equated this QTL with Pas1. However, since Pas1 was orginally mapped in J:17778, in 1997 using an (C57BL/6J x A/J)F2 intercross where the direction of the cross varied from that of the cross used here we consider this a separate map experiment and have labeled this QTL, Pas15. This locus is 50% of the genetic variance.

Significant association mapped to approximately 16 cM on mouse Chromosome 19 between D19Mit42 and D19Mit19. This locus is called Pas3 and explains 10% of the genetic variance. Candidate genes mapping near Pas3 are Tnfrsf6 (formerly Fas) and Slc3a2 (formerlyMdu1).

12.14.2015. Curator Note: Pas3 was originally mapped in J:21801 using pooled results from a (C57BL/6JOlaHsd x A/JOlaHsd)F2 intercross population and (C57BL/6JOlaHsd x A/JOlaHsd)F1 x A/JOlaHsd and (C57BL/6JOlaHsd x A/JOlaHsd)F1 x C57BL/6JOlaHsd backcross populations. Because the direction of the cross used to generate the F1 female differs in this study we consider this a separate map experiment and have named the QTL Pas16.

Pas15 and Pas16 appear to interact. Heterozygosity at both Pas15 and Pas16 confers increased tumor count compared to the other genotypes.

References

• Original: J:22173 Devereux TR, et al., Assignment of a locus for mouse lung tumor susceptibility to proximal chromosome 19. Mamm Genome. 1994 Dec;5(12):749-55
• All: 1 reference(s)